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(15-19) Liraglutide was found to improve bone microarchitecture and restore bone mass in rats with diabetic osteoporosis, as evidenced by upregulation of Wnt/-catenin signaling and suppression of RANKL expression, leading to increased OPG and osteocalcin levels

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The brief estimates that unauthorized GLP-1 compounding could reduce future pharmaceutical R&D investment by between $9.3 billion and $11.8 billion, potentially resulting in four to five fewer new medicines being developed