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(I am a big advocate of spacing out doses for people who have reached their goal weight, OR who are taking GLP-1s primarily for a possible metabolic/anti-inflammatory benefit, and who want to keep their weight neutral.) But maintenance dosing after achieving a clinical response is a completely different concept from starting at a sub-therapeutic dose and hoping it works

doi:10.1126/science.8351519

The increasing prevalence of obesity worldwide and its associated pressure on healthcare systems, along with the reputation of GLP-1 drugs for inducing significant weight loss (approximately 1525+%, significantly higher than previous generations of obesity drugs), are driving GLP-1 drug expansion into new markets like China

Thoroughly wash the glutathione Sepharose with 510 bed volumes (see Note 16) PBS at 1.5 ml/min to remove the ethanol storage solution