A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation
10.1210/endrev/bnac033 11 DarbalaeiS.ChangR
GNCs GLP-1 support section has performed exceptionally well, and the entire weight management category has been seeing impressive growth, Butera says
For people with rheumatoid arthritis (RA), lupus, psoriatic arthritis, or osteoarthritis, this chronic inflammation means more pain, swelling, stiffness, mobility problems, and tissue damage. Whats most shocking: unchecked inflammation is the root of many chronic diseasesRA, diabetes, gout, heart diseaseand doubles your risk of heart attack, stroke, and even premature death