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Studies investigating the relationship between mtDNA copy number and the risk of kidney disease progression have revealed a negative correlation between serum mtDNA copy number levels and the progression of CKD and renal failure in individuals of both black and white ethnicities with mild to moderate CKD, as well as in patients with diabetes mellitus, and patients with albuminuria ( 2.2 Mitochondrial respiratory chain damaged and DN The mitochondrial respiratory chain (MRC) is the basic structure of OXPHOS and occupies a central position in cellular energy metabolism

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