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Important safety considerations that have been reinforced include: Monitoring for signs of pancreatitis (severe, persistent abdominal pain) Awareness of thyroid C-cell tumours observed in rodent studies (the risk in humans is unknown) [7] [2] Tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis [15] [1] Potential for acute kidney injury secondary to dehydration from gastrointestinal effects The ongoing SURPASS-CVOT trial, evaluating cardiovascular outcomes with tirzepatide, is expected to provide crucial data in 2025 regarding long-term cardiovascular safety and potential benefits

The medication improves insulin sensitivity and may reduce systemic inflammationfactors that have been implicated in OSA pathogenesis independent of body weight

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If more than 4 days have passed since your scheduled dose, skip that dose entirely and take the next one on your regular day