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In the pivotal SUSTAIN clinical trial programme, which evaluated semaglutide across various doses and patient populations, the frequency of gastrointestinal symptoms varied by dose
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Standard reconstitution (recommended): - 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL concentration - At this concentration: 0.1 mL (10 units on an insulin syringe) = 0.5 mg MT-II - 0.05 mL (5 units) = 0.25 mg MT-II Alternative (simpler math): - 10 mg vial + 1 mL bacteriostatic water = 10 mg/mL concentration - At this concentration: 0.05 mL (5 units) = 0.5 mg MT-II - More concentrated, but each unit mark on the syringe represents a larger dose, making small dose adjustments harder Step-by-step mixing: 1
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