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Unlike other GHRPs, Ipamorelin has been shown in animal models to exhibit high selectivity for growth hormone release without significantly affecting cortisol, prolactin, or ACTH levels

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In contrast, NP4 remained cytotoxic in a 1% and 21% O 2 atmosphere

Its defining trait in the research literature is selectivity: unlike older GHRPs such as GHRP-6 or GHRP-2, ipamorelin is reported to release GH without meaningfully raising cortisol, prolactin, ACTH, or aldosterone, and with only minimal appetite stimulation