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More recently, a randomized, double-blind, placebo-controlled trial in 215 men, aged 35 to 55 years, examined the effects of supplemental B vitamins (at 3 to 13 times the current RDA, except for folic acid which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), and the minerals, zinc (10 mg/day), calcium (100 mg/day), and magnesium (100 mg/day) on mood and perceived stress (134)

Indeed, when the mice were treated with antioxidants in addition to the drug, the therapeutic effects were diminished and their metastatic tumor burden increased

Studies have shown that oral supplements of B12 and injections both offer effective treatment of deficiencies

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