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Already taking GLP-1s

Managing Side Effects If you experience back pain or musculoskeletal discomfort while taking semaglutide, there are several strategies to manage these symptoms: Speak With Your Healthcare Provider Report any new or worsening back pain to your doctor

Try eating it at the start of your day or before meals to slow digestion and boost satiety sooner

Notably, SR18 occupied the same orthosteric binding pocket on both conformers of GLP-1R, a binding site typically occupied by GLP-1 and other similar peptide mimetics, as evidenced in reported structural studies (Zhang et al., 2017