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A few months later, in January 1987 the group reported that the porcine peptide stimulated a small increase of insulin secretion from an isolated perfused pig pancreas and that they had observed a similar effect with a synthetic replica of the natural hormone

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Effect of metformin on insulin production in MIN6 cells treated with GLP-1 (a) or GIP (b) in the presence of 5.5 or 16.7 mM glucose