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Hauptman-Woodward Medical Research Institute, Buffalo, New York 14203, USA

Additional information Peer review information Nature Communications thanks Rohini Kuner, Sabine Lvi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

The open-label, single-arm pilot study conducted by Handog et al

Initial improvements are often noticeable within 46 weeks , with full results becoming evident around 612 weeks , as the body gradually processes the destroyed fat through the lymphatic system