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To determine the role of the VSMC GLP-1R in GLP-1RAinduced renal hemodynamic responses, GFR was measured in Glp1r VSM+/+ and Glp1r VSM/ mice following acute semaglutide injection

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Analgesic Potency in Pre-Clinical Pain Models , Pre-clinical analgesia studies have documented Dermorphins potent analgesic activity across hot plate, tail flick, and inflammatory pain models , with studies reporting analgesic potency substantially exceeding that of morphine on a molar basis following central administration, consistent with its high MOR binding affinity and full agonist efficacy at pain-processing MOR populations

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