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Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

This is important, because we now recognize that the buildup of mitochondrial waste products is one of the most important contributors to insulin resistance, which further promotes high blood sugar and obesity

Only MsrB1 has been characterized as a selenoprotein with one selenocysteine residue in its catalytic site