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Turicchi, J

While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings

In addition, GLP-1RAs exert pleiotropic effects by promoting weight loss, activating GLP-1 receptors on neurons and T cells, and targeting receptors in multiple organs

Cognitive behavioral therapy, structured coaching, or digital health tools may strengthen adherence and motivation