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Activated postsynaptic CB1 receptors bind to NMDAR1 subunits and promote NMDAR internalization [98]

Common side effects may include: Nausea: Especially after meals or following a dose increase Vomiting: Triggered by persistent or severe nausea Constipation: Due to slower digestion and reduced food intake Diarrhea: Including loose stools or changes in bowel habits Bloating: Caused by delayed stomach emptying Abdominal discomfort: Such as mild cramping, pressure, or digestive upset Tips to manage GLP-1 side effects Reduce portion sizes Many patients find that eating smaller meals helps reduce nausea and digestive discomfort

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