humanized glp-1 receptor knock-in mouse Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 expression and signaling hGLP1R—Humanized GLP-1 Receptor Knock-in Mouse

21 GulloF.CerianiM.DAloiaA.WankeE.ConstantiA.CostaB.et al (2017)

5 Enhances Insulin Sensitivity & Blood Sugar Control Fasting stabilizes blood sugar levels by reducing insulin resistance, a major contributor to diabetes, metabolic syndrome, and weight gain

Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

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