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[2] Semaglutide works through several complementary mechanisms: it stimulates insulin secretion from the pancreas when blood glucose levels are elevated, suppresses the release of glucagon (a hormone that raises blood sugar), slows gastric emptying to reduce post-meal glucose spikes, and acts on appetite centres in the brain to promote satiety and reduce food intake

Quantitative real-time PCR RNA was reverse-transcribed using the RevertAid First Strand cDNA Synthesis Kit (Thermo Scientific, Waltham, MA, USA)

Moreover, this might be an NO-system-related effect