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These data are consistent with our prior observation that TBHP sensitizes LCS3-resistant cells to LCS3 and suggest that inhibition of both GSR and TXNRD1 contributes to LCS3-induced toxicity

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As highlighted in the recently published first Australian evidence-based guidelines on male infertility, male fertility is increasingly recognised as a sensitive indicator of overall male health, reflecting the cumulative effects of metabolic, endocrine and environmental influences across the lifespan