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Regulation of Met metabolism in the liver In the liver, when the consumption of Met exceeds its average dietary intake, de novo synthesis of Met occurs via the transfer of a methyl group from methylene-THF first by methylene-THF reductase (MTHFR) and then by Met synthase (MS) to Hcy to form Met to make up the difference (8, 9) (Figure 2)

Store in sealed condition at room temperature (1-30C) Professional administration required via IV infusion Keep out of reach of children Use only as directed by healthcare provider Contraindications and Precautions Do not use if pregnant or breastfeeding Consult doctor before use if you have pre-existing medical conditions Check for medication interactions before treatment Open ampoules with caution to prevent glass contamination Storage and Handling Instructions Store at room temperature between 1-30C Keep in original sealed packaging until use Protect from direct sunlight and extreme temperatures Use within shelf life - 2 years from manufacturing date Frequently Asked Questions Q

It inhibits tyrosinase, the enzyme that pigment-producing cells (melanocytes) use to make melanin

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