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The authors thank Christopher Quinn from English Consulting Brazil for the English revision

It's also important to understand that microneedling results are not permanent natural aging and collagen degradation continue over time, so maintenance treatments may be recommended

[27] Vitamin B 12 deficiency has the potential to influence methylation patterns in DNA, besides other epigenetic modulators such as micro (RNAs), leading to the altered expression of genes

27 30 The current research highlights the importance of patient-reported safety in primary care because they highlight issues that clinicians may not recognise 31 and provide a framework for future directed learning to reduce safety incidents