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64 These insulin-sensitive tumors also regressed in response to 60% CR, and insulin treatment in vitro induced a parallel rise of DNA synthesis and DNA polymerase activity

Structured, small meals are preferable to prolonged fasting

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In line with Danish clinical guidelines, patients were modelled as remaining on the trial medications until the HbA1c level target of 7.5% was exceeded by 0.5% [38] (i.e., when the HbA1c level crossed 8.0%), at which point a switch to a basal insulin (+ metformin) regimen was estimated and treatment effects of trial medications were reversed across biomarkers