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non-steroidal anti-inflammatory drugs (NSAIDs) can cause acute renal failure, interstitial nephritis and glomerulonephritis (Table 1)

On the other hand, an elevated concentration of homocysteine, and its metabolites such as homocysteine thiolactone and N-homocysteinyllysine result in health problems and has been indicated as an independent risk factor for cardiovascular disease and accelerated atherosclerosis

It has been shown that multiple apoptosis-regulating proteins are substrates for lysosome-derived cathepsins, including Bid, Bcl-2, Bcl-XL, and XIAP [62]

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