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doi: 10.1016/j.redox.2020.101483 31 YangJHFriederichMWEllsworthKAFrederickAForemanEMalickiDet al

Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

A second approach has been to enhance glutathione biosynthesis by activating the transcription factor Nrf2 (13)

Retatrutide also significantly upregulated the key transcriptional regulators of fatty acid oxidation, Ppara (2.33-fold) and Ppargc1a (1.56-fold), and restored the expression of genes involved in peroxisome biogenesis (e.g., Pex19 , 2.02-fold