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They include nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), activator protein 1 (AP-1), p53, and nuclear factor erythroid 2-related factor 2 (NRF2) (219, 220)

Recognizing and responding to this challenge, the European Commission funded Framework 7 MErCuRIC programme is running a biomarker-enriched clinical trial investigating the efficacy of combined c-MET/MEK inhibition in patients with RAS -mutant or RAS -wild-type metastatic colorectal cancer with aberrant c-MET expression