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Common contraindications cited in the research-use community include: anyone with active or recent cancer (BPC-157 and TB-500 promote angiogenesis), people with Wilson's disease or other copper-metabolism disorders (GHK-Cu component), anyone pregnant or breastfeeding (no safety data), and athletes subject to WADA testing (BPC-157 and TB-500 are prohibited)

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In the IVD, melatonin diminished cellular apoptosis caused by tert-butyl hydroperoxide, maintained ECM production, and suppressed the expression of degenerative enzymes, including MMP-13 and ADAMTS-5, in NP cells

10.1042/bj3200383 Biochem