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First-in-human trial underway evaluating ATR-258's selective 2-adrenergic signaling in muscle Oral, first-in-class therapy aims to drive fat loss while preserving or increasing muscle mass Built on GRK2-biased signaling pathway to avoid traditional cardiovascular side effects Backed by 2025 Cell Press publication validating novel mechanism of action Signals growing momentum behind next-generation obesity therapies beyond GLP-1s ------------------------------------------------------------- Stay up to date with everything obesity through my newsletter To view or add a comment, sign in The ODYSSEY-#HCM findings were neutral from a clinical standpoint: Mavacamten use did not result in improved peak oxygen consumption or patient-reported health status in those with nonobstructive hypertrophic cardiomyopathy despite reverse remodeling as suggested by echocardiographic and plasma biomarker levels

The Outsourcing Facilities Association filed a legal challenge in February 2025, but the regulatory direction is clear: the era of widely available compounded GLP-1s is closing

Foliar Feeding of Plants with Amino Acid Chelates

Addiction: The Dark Night of the Soul/ Nad+: The Light of Hope Paula Norris Mestayer Google Books