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Abstract Introduction: Administration of high doses of acetaminophen (APAP) results in liver injury

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At physiological pH, cytochrome c has a net positive charge (+8), establishing an electrostatic bond with the anionic cardiolipin (Gonzalvez and Gottlieb, 2007)

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Yet another route of glutathione degradation would involve cleavage of the glycine by a carboxypeptidase activity (Steinkamp and Rennenberg, 1985)

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Background Substance use disorder is a leading public health concern, affecting approximately 40 million people worldwide

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