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Associated symptoms that should prompt immediate medical attention include: Persistent nausea and vomiting that prevents oral intake Abdominal tenderness and distension Fever and rapid heart rate Jaundice (yellowing of skin or eyes) in cases involving biliary obstruction If severe, persistent upper abdominal pain occurs, patients should stop their GLP-1 injection immediately and seek urgent medical assessment
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A crowded field of next-generation contenders is also pushing forward: Amgen's AMG 133, Roche's GLP-1/GIP co-agonists, AstraZeneca's cotadutide, and Phase 2 candidates like HRS9531 and MariTide (a GLP-1 agonists plus GIP antagonist) are all showing early promise in obesity treatment
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