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And patients who could benefit - the normal-weight person with insulin resistance, fatty liver, and creeping inflammatory markers - never get offered them

My only hesitation in accepting the hypothesis that obesity is a downstream effect of hypothalamic inflammation lies in the fact that, in metabolically healthy individuals, a normally functioning digestive system, a non-steatotic liver, nutrient-sensitive pancreas and intestine, insulin-sensitive adipose tissue, should mitigate, at least to some extent (though not completely), the negative effects of an unhealthy diet, until their compensatory capacity fails

termed TK is composed of 913 aminoacids encoded by gene TKTL2 located on chromosome 4 having length of 2742 bp [94]