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An international study combining single-cell genomics, spatial transcriptomics and artificial intelligence has identified large-scale changes in three-dimensional genome organisation in Alzheimers-affected brain cells, establishing chromatin architecture as a previously overlooked component of the diseases molecular pathology and a potential framework for future therapeutic targeting

You are working with tiny volumes where small errors translate to meaningful dose variations

When NNMT is overactive, less nicotinamide is available for recycling, and cellular NAD+ levels fall

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