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Description

Long-term nasal spray use carries theoretical concerns about mucosal damage

Overexpression of wild-type USP1 , but not its catalytically inactive mutant, led to increased BMAL1 protein abundance, whereas USP1 knockdown via shRNA or CRISPR knockout significantly reduced BMAL1 levels in U2OS cells (Hu et al., 2024)

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Furthermore, there have not been any studies that show that B12 can become toxic or cause any problems (8) (as long as your kidneys are functioning (9))