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Jen de Simone says, "People are microdosing so they get the anti-inflammatory effects without significant weight loss." David Kellner, MD: I would say again, at this time there is no robust clinical evidence demonstrating that microdosing GLP-1-based therapies provides anti-inflammatory benefit separate from weight loss

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If you're resistant to GLP-1, you're not getting its appetite-suppressing effects, which makes you more likely to eat more junk food, which only adds to the blood sugar problems that are keeping you resistant to GLP-1 in the first place