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By age 70, about 70% of men experience some degree of erectile difficulty

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The phenotype is thought to arise due to deficits in cerebral energy production during and after fetal development, the accumulation of the potentially neurotoxic guanidinoacetate and other guanidino compounds, and possible abnormalities in ongoing neural signaling associated with abnormalities in the creatinephosphocreatine system (88)

GLP-1 therapy may be appropriate for individuals who: Have struggled with weight despite consistent effort Experience significant hunger or food cravings Have insulin resistance Have obesity-related health concerns Want medically supervised weight loss support A personalized evaluation is necessary to determine whether treatment is appropriate