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The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism is unsettled: the tempting "it is the drugs signaling arm" story is ruled out, because the strongest GLP-1 signaler in the class carries no such signal

Nonetheless, healthcare providers may prescribe it off-label for weight loss

However, retatrutides long-term safety, side effects, and overall impact are still under investigation

Mary ONeill, interim chief medical officer of the American Red Cross, said in a statement that this study needs confirmation as conflicting studies also existAs further research is required, we do not anticipate a change to the standard blood donation criteria or current conservative transfusion practices at this time