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Generally, low cardiovascular risk is typically defined as the absence of cardiovascular disease and a Flemingham 10-year risk of cardiovascular events less than 20% ( Conclusion In conclusion, our meta-analysis showed that first-line use of SGLT2i and GLP-1RAs in T2DM patients at low cardiovascular disease risk significantly reduced HbA1c, body weight, and FPG levels in T2DM patients compared with placebo

The mechanism works regardless of starting body fat level, though individuals with BMIs above 40 may benefit from the full 12mg dose more than those in the 30-35 BMI range

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