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IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines

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Tamoxifen treatment caused a significant reduction in the expression of Trp53 in adipocytes isolated from eWAT, sWAT, and in bulk BAT of CreERT2-positive mice, whereas the expression of Trp53 in liver and skeletal muscle remained unaltered (Supplementary Fig

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