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Women using oral contraceptives should use a non-oral method or add a barrier method for 4 weeks after starting treatment and for 4 weeks after each dose increase

de Ceglia M, Decara J, Gaetani S, de Fonseca FR (2021) Obesity as a Condition determined by Food Addiction: should Brain Endocannabinoid System alterations be the cause and its Modulation the Solution

The same review notes that real-world data show up to 65% of GLP-1 receptor agonist users discontinue within a year of initiation, which makes this a common rather than rare trajectory

While monthly GLP-1 formulations may become commercially available soon in higher-income regions, other geographies especially those with high expected biosimilar penetration may continue relying on weekly-dosed drugs for the foreseeable future