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[5] The precise numeric half-life in a human being is unknown, and any specific figure presented as established human pharmacokinetics is not evidence-based

Following local radiotherapy combined with systemic anlotinib treatment, the patient achieved prolonged progression-free survival (PFS) exceeding 32 months

Besides eNOS uncoupling, inhibition of the enzyme may also result in a significant drop in vascular NO levels, resulting in endothelial dysfunction and alterations in vascular tone, which may lead to hypertension