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Similar patterns of familial clustering have been noted in RA patients, underscoring the significant role of genetic factors in disease onset

These include eczema, dermatitis (contact, atopic, seborrheic, nummular), tinea, lichen planus, lichen simplex, pityriasis rosea, cutaneous lupus erythematosus, syphilis, drug reactions, squamous cell carcinoma in situ, and mycosis fungoides (cutaneous T-cell lymphoma) (Armstrong 2014

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Independence From Nitric Oxide Vasodilation: Unlike PDE-5 inhibitors such as sildenafil, PT-141 does not primarily increase nitric oxide production or inhibit phosphodiesterase enzymes