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[0017] In some particular embodiments of the present invention, the coupling in the fragmental synthesis of the Lys 26 side chain in the preparation method is performed by condensing with DIC+A or B+A+C until the resin is detected to be transparent with ninhydrin, wherein A is chosen from HOBt or HOAt, B is chosen from HBTU, HATU, TBTU, PyAOP, or PyBOP, C is chosen from DIPEA or TMP

Although we did not find any piece of literature with evidence to support a reverse causality between RA and CTS, we still performed a reverse MR analysis for rigor reasons

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The most common side effects are nausea, vomiting, diarrhea, abdominal pain and constipation