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While initially hyperglycaemia results in osmotic stress, the lens is able to regulate its volume through osmoregulatory mechanism that can accommodate small changes in osmotic pressure [33]

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Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/-catenin signaling pathway

We also studied the consequences of PA treatment on the expression of other well-known ferroptosis-related genes and found that PA induced a decreased expression of two key anti-ferroptotic genes: the gluthatione peroxidase 4 (GPX4) and the ferroptosis suppressor protein 1 (FSP1) and an enhanced expression of two key pro-ferroptotic genes: the arachidonate 15-lipoxygenase (ALOX15) and the acyl-CoA synthetase long chain family member 4 (ACSL4)