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doi:10.1164/rccm.200508-1223OC Singh TD, Patial K, Vijayan VK, Ravi K

Castration-induced increases in insulin-like growth factor-binding protein 2 promotes proliferation of androgen-independent human prostate LNCaP tumors

These pseudo-observations serve to anchor the doseresponse relationship at a physiologically plausible baseline (i.e., no treatment effect in the absence of exposure), thereby preventing unrealistic extrapolation near zero dose