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doi: 10.1002/oby.24274 42 OldVJDaviesMJPapamargaritisDChoudharyPWatsonEL

Individuals with diagnosed vitamin D deficiency, certain medical conditions affecting absorption (like celiac disease or chronic kidney disease), and those unable to take oral supplements may need vitamin D3 injections

It was synthesized mainly through genetic engineering and other biological methods, which involved technical difficulties and high production costs and was inconducive to large-scale production

Inherited disorders of vitamin B 12 absorption Rare cases of inborn errors of vitamin B 12 metabolism have been reported in the literature (reviewed in 6)