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Emerging evidence indicates that TIM-3 can promote ferroptosis in T cells by suppressing AMP-activated protein kinase (AMPK) signaling and enhancing lipid peroxidation (144)
AbderrezagNSnchez-MartnezJDLouaerOMeniaiA-HMendiolaJA
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The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis
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