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Microdosing these medications has been linked to reduced levels of pro-inflammatory cytokines like IL-6 and TNF- , which play roles in autoimmune diseases, cardiovascular risk, and aging-related decline

Given no known difference in efficacy on antidepressant effects, bupropion should be considered the best initial choice of antidepressant in depressed overweight and obese patients when no known contraindications are present