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Restoration of altered endogenous neurosteroid levels via modulation of steroidogenesis mediated by pregnane xenobiotic receptors (PXR) and the endocannabinoid system has been suggested as an alternative to direct administration of neurosteroids (89, 178, 337)

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The dual-mechanism approach may also offer specific advantages for particular patient subgroups, including those with type 2 diabetes and obesity where cardiometabolic improvements beyond weight loss are clinically important