SURPASS-4, a multicenter open-label RCT comparing treatment with tirzepatide and insulin glargine in T2D patients at increased CV risk for a median of 85 weeks, was the only study in the SURPASS program to include the change from baseline in eGFR and UACR and occurrence of eGFR decline of at least 40%, renal death, progression to end-stage kidney disease or new-onset MA among the prespecified analyses [48]
Source: Journal reference: Hecht, F
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In research settings, GLP-1 SM is used to investigate GLP-1 receptor signaling, incretin physiology, gastric emptying, appetite regulation, and metabolic homeostasis relevant to obesity and type 2 diabetes