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Shrinkage regressions were applied, which resulted in building a new FPLD1-PRS of 80 SNPs with a top decile OR of 3.27 (P=2e-16) in UK Biobank and validated in the Oxford Biobank (n=4,547) showing OR of 2.51 ( P=3.13e-05 )

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Post-Exertional Malaise (PEM): By dismantling the immune system's "energy sink," this formula helps free up ATP reserves for the muscles and brain, potentially increasing the threshold for physical and cognitive exertion before a crash occurs

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