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Because no large prospective human trials have been conducted using direct measurements of GSH, this review focused on the more common biomarker gamma-glutamyl transferase (GGT) which is directly correlated to low GSH levels

For a patient with untreated Cushings disease or on high-dose glucocorticoid therapy, an elevated serum IGF-I may be observed, but levels decrease following remission or cessation of glucocorticoid therapy, respectively

Participants completed psychological rating scales to assess symptoms and depression

Research and clinical experience suggest that IV NAD+ produces a sharp but short-lived spike in plasma levels that does not reliably translate to intracellular increases, which is where the therapeutic effect actually happens