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Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects

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Key points: Orforglipron, a once-daily non-peptide oral GLP-1 pill, has shown weight loss results similar to peptide-based GLP-1 medications in early clinical trial data